Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome
Identifieur interne : 004440 ( Main/Exploration ); précédent : 004439; suivant : 004441Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia‐related syndrome
Auteurs : M. Willems [Belgique] ; L. Sheng [Belgique] ; T. Roskams [Belgique] ; B. Ramdani [Belgique] ; J. M. Doutrelepont [Belgique] ; F. Nevens [Belgique] ; P. Durez [Belgique] ; S. Treille [Belgique] ; M. Adler [Belgique] ; V. Desmet [Belgique] ; J. Fevery [Belgique] ; S. H. Yap [Belgique]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 1994-11.
English descriptors
- Teeft :
- Assay, Biopsy, Biopsy specimens, Chronic hepatitis, Clinical evidence, Clinical features, Clinical manifestations, Clinical practice, Concomitant infection, Consecutive patients, Cryoglobulinemia, Cryoglobulinemia type, Cryoglobulins, Diffuse glomerulonephritis, England journal, Genotype, Genotype prevalence, Genotyping, Glomerulonephritis, Hepatitis, Hepatocellular carcinoma, High prevalence, Infection, Interferon, Interferon therapy, Internal medicine, Kallestad diagnostics, Kidney biopsy, Liver biopsy, Liver disease, Membranoproliferative glomerulonephritis, Membranous glomerulonephritis, National academy, Negative patients, Noncoding region, Pancreatic diseases, Positive hbsag, Positive patients, Possible association, Progressive glomerulonephritis, Rheumatoid arthritis, Rheumatoid factor, Room temperature, Second generation, Serologic reactivities, Synovial biopsy, University hospital gasthuisberg, Urinary protein, Virology, Virus infection.
Abstract
Recently, evidence has been presented for a possible association between hepatitis C virus (HCV) infection and essential mixed cryoglobulinemia (EMC). Eleven consecutive patients with EMC and two with cryoglobulinemia type I were examined for the presence of markers of HCV infection. Eleven of 13 patients (10 with EMC and 1 with type I cryoglobulinemia) had anti‐HCV antibodies (as determined by a second generation anti‐HCV assay) and HCV‐RNA in plasma or serum. HCV‐RNA was also detected in liver biopsies of five patients. Genotyping showed that HCV genotype 1 was found in 10 of 11 patients with HCV‐RNA (9 genotype 1b and 1 genotype 1a) and only one patient had HCV genotype 2. However, a similar high prevalence of genotype 1b (100%) was found in a group of 14 consecutive patients with chronic hepatitis C, who had no clinical evidence of cryoglobulinemia. Concomitant infection was present in three patients with genotypes 2, 3 and 4, respectively. These findings stress the high prevalence of HCV infection in patients with EMC and further study shows that a difference in genotype prevalence was not found between HCV‐related EMC and chronic hepatitis C without clinical manifestations of EMC. © 1994 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.1890440310
Affiliations:
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Adler</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>Hǒpital Universitaire Erasme, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Desmet, V" sort="Desmet, V" uniqKey="Desmet V" first="V." last="Desmet">V. Desmet</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pathology, University Hospital Sint‐Rafaël, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Fevery, J" sort="Fevery, J" uniqKey="Fevery J" first="J." last="Fevery">J. Fevery</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Yap, S H" sort="Yap, S H" uniqKey="Yap S" first="S. H." last="Yap">S. H. Yap</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, University Hospital Gasthuisberg, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Belgique</country><wicri:regionArea>Correspondence address: Division of Liver and Pancreatic Diseases, Department of Internal Medicine, University Hospital Gasthuisberg, B‐3000 Leuven</wicri:regionArea><wicri:noRegion>B‐3000 Leuven</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">44</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="266">266</biblScope><biblScope unit="page" to="271">271</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1994-11">1994-11</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Assay</term><term>Biopsy</term><term>Biopsy specimens</term><term>Chronic hepatitis</term><term>Clinical evidence</term><term>Clinical features</term><term>Clinical manifestations</term><term>Clinical practice</term><term>Concomitant infection</term><term>Consecutive patients</term><term>Cryoglobulinemia</term><term>Cryoglobulinemia type</term><term>Cryoglobulins</term><term>Diffuse glomerulonephritis</term><term>England journal</term><term>Genotype</term><term>Genotype prevalence</term><term>Genotyping</term><term>Glomerulonephritis</term><term>Hepatitis</term><term>Hepatocellular carcinoma</term><term>High prevalence</term><term>Infection</term><term>Interferon</term><term>Interferon therapy</term><term>Internal medicine</term><term>Kallestad diagnostics</term><term>Kidney biopsy</term><term>Liver biopsy</term><term>Liver disease</term><term>Membranoproliferative glomerulonephritis</term><term>Membranous glomerulonephritis</term><term>National academy</term><term>Negative patients</term><term>Noncoding region</term><term>Pancreatic diseases</term><term>Positive hbsag</term><term>Positive patients</term><term>Possible association</term><term>Progressive glomerulonephritis</term><term>Rheumatoid arthritis</term><term>Rheumatoid factor</term><term>Room temperature</term><term>Second generation</term><term>Serologic reactivities</term><term>Synovial biopsy</term><term>University hospital gasthuisberg</term><term>Urinary protein</term><term>Virology</term><term>Virus infection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, evidence has been presented for a possible association between hepatitis C virus (HCV) infection and essential mixed cryoglobulinemia (EMC). Eleven consecutive patients with EMC and two with cryoglobulinemia type I were examined for the presence of markers of HCV infection. Eleven of 13 patients (10 with EMC and 1 with type I cryoglobulinemia) had anti‐HCV antibodies (as determined by a second generation anti‐HCV assay) and HCV‐RNA in plasma or serum. HCV‐RNA was also detected in liver biopsies of five patients. Genotyping showed that HCV genotype 1 was found in 10 of 11 patients with HCV‐RNA (9 genotype 1b and 1 genotype 1a) and only one patient had HCV genotype 2. However, a similar high prevalence of genotype 1b (100%) was found in a group of 14 consecutive patients with chronic hepatitis C, who had no clinical evidence of cryoglobulinemia. Concomitant infection was present in three patients with genotypes 2, 3 and 4, respectively. These findings stress the high prevalence of HCV infection in patients with EMC and further study shows that a difference in genotype prevalence was not found between HCV‐related EMC and chronic hepatitis C without clinical manifestations of EMC. © 1994 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li></settlement></list><tree><country name="Belgique"><noRegion><name sortKey="Willems, M" sort="Willems, M" uniqKey="Willems M" first="M." last="Willems">M. Willems</name></noRegion><name sortKey="Adler, M" sort="Adler, M" uniqKey="Adler M" first="M." last="Adler">M. Adler</name><name sortKey="Desmet, V" sort="Desmet, V" uniqKey="Desmet V" first="V." last="Desmet">V. Desmet</name><name sortKey="Doutrelepont, J M" sort="Doutrelepont, J M" uniqKey="Doutrelepont J" first="J. M." last="Doutrelepont">J. M. Doutrelepont</name><name sortKey="Durez, P" sort="Durez, P" uniqKey="Durez P" first="P." last="Durez">P. Durez</name><name sortKey="Fevery, J" sort="Fevery, J" uniqKey="Fevery J" first="J." last="Fevery">J. Fevery</name><name sortKey="Nevens, F" sort="Nevens, F" uniqKey="Nevens F" first="F." last="Nevens">F. Nevens</name><name sortKey="Ramdani, B" sort="Ramdani, B" uniqKey="Ramdani B" first="B." last="Ramdani">B. Ramdani</name><name sortKey="Roskams, T" sort="Roskams, T" uniqKey="Roskams T" first="T." last="Roskams">T. Roskams</name><name sortKey="Sheng, L" sort="Sheng, L" uniqKey="Sheng L" first="L." last="Sheng">L. Sheng</name><name sortKey="Sheng, L" sort="Sheng, L" uniqKey="Sheng L" first="L." last="Sheng">L. Sheng</name><name sortKey="Treille, S" sort="Treille, S" uniqKey="Treille S" first="S." last="Treille">S. Treille</name><name sortKey="Willems, M" sort="Willems, M" uniqKey="Willems M" first="M." last="Willems">M. Willems</name><name sortKey="Yap, S H" sort="Yap, S H" uniqKey="Yap S" first="S. H." last="Yap">S. H. Yap</name><name sortKey="Yap, S H" sort="Yap, S H" uniqKey="Yap S" first="S. H." last="Yap">S. H. Yap</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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